| Sandar, Senator | chimpanzee | male | POTA (2001), POTA: Force, POTA: Resistance | Warner, David | inhabitant of ape city of Derkein, father of Ari |
| Sarai | human | female | POTA: Force, POTA: Resistance | chief of Tek clan, born of Wilding father; mother of Daena, married to Karubi | |
| Semos | chimpanzee | male | POTA: The Fall | né Jonathan, fostered by Molly Benavides; founder of ape colony, husband of Aspasia, father of Thados and Zaius | |
| Seneca | gorilla | male | Human War (Dark Horse Comics) | rebel soldier | |
| Skipper | human | male | Beneath the POTA | Andrews, Tod | real name not given in film; commanding officer of Lt. John Brent on reconnaissance trip for Col. Taylor; married, 2 daughters; dies after crash landing |
| Spokka | ape | Return to the POTA Ep. 4 "Tunnel of Fear" | character from ape television series "Spokka the Space-Ape" | ||
| Stanton, Doctor | human | male | Return to the POTA | scientist who developed the theory of "time thrust", which NASA Venturer crew sets out to test | |
| Stewart, Lieutenant | human | female | POTA (1968) | Stanley, Dianne | one of 4-member crew aboard Icarus; dies en route due to leak in cryogenic chamber |
| Suni | human | male | POTA: Resistance | member of Tek clan (?), father of Tarik | |
| Surgora the Bold | gorilla (?) | male | Return to the POTA Ep. 4 "Tunnel of Fear" | historical reference: 100 years prior, Surgora, of the greatest ape generals, attempted to cross Forbidden Zone with his forces and failed |